Rebis Research Institute

The Rebis Research Institute is our outcomes‑research and data‑analytics arm. We capture real‑world results across all Rebis programs, design prospective studies, and publish peer‑reviewed evidence showing how integrative, airway‑focused sleep care improves health and lowers costs.

Areas of focus

  • Clinical effectiveness of multidisciplinary sleep interventions

  • Health‑economics: cost‑effectiveness and return‑on‑investment analyses

  • Functional‑medicine outcomes & biomarker discovery

  • Airway dentistry impact on cardiometabolic risk

  • Digital and remote monitoring technologies

  • Pediatric sleep health and long‑term development

Conditions we treat

  • Obstructive sleep apnea

  • Insomnia

  • Pediatric sleep disorders

  • Chronic fatigue

  • Cardiometabolic and neurocognitive conditions linked to sleep loss

Our approach

  • Prospective patient registries & pragmatic trials with IRB oversight

  • Practice‑based research network and academic partnerships

  • Advanced analytics & AI to mine EHR and wearable data

  • Transparent reporting—preprints, peer‑reviewed journals, and open‑data summaries

  • Continuous feedback loops to clinicians for rapid quality improvement

Who benefits

Patients receive care informed by the latest evidence; payers and employers gain proof of lower costs; health systems and policymakers get validated models for value‑based sleep care.

How it improves sleep & health

By turning real‑world data into actionable insights, we accelerate adoption of therapies that shorten diagnostic journeys, raise adherence, and cut per‑patient costs—ultimately improving population health while bending the cost curve.

  • Beidelschies M, Alejandro-Rodriguez M, Ji X, Lapin B, Hanaway P, Rothberg MB. Association of the Functional Medicine Model of Care With Patient-Reported Health-Related Quality-of-Life Outcomes. JAMA Netw Open. 2019;2(10):e1914017. 

    Beidelschies M, et al. Patient outcomes and costs associated with functional medicine-based care in a shared versus individual setting for patients with chronic conditions: a retrospective cohort study. BMJ Open 2021;11:e048294. doi:10.1136/bmjopen-2020-048294Whetten J et al. Health resource utilization and cost impact of integrative medicine services for newly diagnosed chronic pain patients. J Int Compl Med, 2024. 30 (11) https://doi.org/10.1089/jicm.2024.0093

    Khazaie S, Mehra R, Bhambra R, Moul DE, Foldvary-Schaefer N, Vanek R, Bena J, Morrison S, Walia HK. Impact of a multidisciplinary sleep apnea management group clinic on positive airway pressure adherence and patient-reported outcomes: a randomized controlled trial. Sleep Breath. 2025 Apr 4;29(2):149.